通过水平离心和异位移植的富含血小板纤维素提升鼻腔地板:随机临床试验
Gabriel Guerra David Reis1, Ricardo Júnior Denardi1, Sergio Luís Scombatti de Souza1
1Department of Oral & Maxillofacial Surgery and Periodontology, Ribeirão Preto School of Dentistry, University of São Paulo-USP, Ribeirão Preto, Brazil.
Clinical implant dentistry and related research
|October 2, 2025
概括
将富含血小板纤维素 (H-PRF) 添加到去蛋白化的牛骨物质 (DBBM) 中,在4个月后显著增强了上鼻膜增大 (MSA) 的新骨形成. 与单独使用DBBM相比,这种组合有望改善骨再生.
科学领域:
- 口腔和牙面部外科手术
- 恢复性牙科 恢复性牙科
- 生物材料科学 生物材料科学
背景情况:
- 上鼻腔增大 (MSA) 对于在缩的上部位放置牙植入物至关重要.
- 脱蛋白牛骨材料 (DBBM) 是一种常见的骨移植替代品.
- 富含血小板纤维素 (PRF) 已经显示出增强骨愈合的潜力.
研究的目的:
- 为了比较DBBM与H-PRF和没有H-PRF在MSA的疗效.
- 在短短4个月的愈合期后评估新的骨形成.
主要方法:
- 一项涉及13名接受双边MSA的患者的分口研究.
- 随机分配单独的DBBM (控制) 或DBBM + H-PRF (测试) 在每个侧面.
- 植入后4个月的微计算机断层扫描 (micro-CT),组织学和组织形态学分析.
主要成果:
- 与DBBM单独组 (45.68%±6.65%) 相比,DBBM+H-PRF组的新形成骨的百分比明显更高 (51.33%±6.17%).
- 微型CT显示,DBBM+H-PRF组的骨体积和连接密度显著增加.
- 基组形状测量分析证实,在添加H-PRF时,骨再生能力较强.
结论:
- 在4个月后,将H-PRF与DBBM结合起来,在MSA中改善了质量和数量上的新骨形成.
- 需要进一步的长期研究来评估对植入物存活和稳定性的影响.
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