口腔状细胞癌的表观遗传向:机制,疗法和翻译潜力
Junting Yang1,2, Xiaoru Yan1,2, Xiaotang Wang1,2
1Laboratory Animal Center, Shanxi Key Laboratory of Experimental Animal Science and Human Disease Animal Model, Shanxi Medical University, Taiyuan, Shanxi, China.
Expert review of anticancer therapy
|October 2, 2025
概括
表观遗传疗法,特别是那些针对非编码RNA (ncRNA) 的疗法,对口腔状细胞癌 (OSCC) 显示出希望. 先进的输送系统和组合策略可以提高治疗疗效和患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 分子生物学分子生物学
背景情况:
- 口腔状细胞癌 (OSCC) 是一种复杂的癌症,预后不佳.
- 像DNA甲基化,基因组修饰和非编码RNA (ncRNA) 调节等表观遗传变化驱动OSCC进展.
- 这些表观遗传变化提供了潜在的治疗点.
研究的目的:
- 审查OSCC的主要表观遗传机制.
- 突出最近在表观遗传治疗剂和OSCC的分子标方面的进展.
- 讨论OSCC表观遗传疗法的新型输送策略和临床试验进展.
主要方法:
- 在PubMed和ClinicalTrials.gov的综合文献搜索 (2002年1月 - 2025年7月).
- 专注于基于ncRNA的调节器 (miRNAs, lncRNAs) 和它们在OSCC中的作用.
- 分析创新的输送系统 (外体,纳米颗粒) 和临床试验数据.
主要成果:
- 基于ncRNA的疗法是OSCC治疗的有希望的候选者.
- 先进的输送系统,如外体和纳米粒子,增强了特异性并克服了耐药性.
- 提供了针对OSCC表观遗传调节者的临床试验的最新情况.
结论:
- 表观遗传疗法为OSCC提供了精确治疗的潜力.
- 组合策略和先进的交付系统可能会加速临床翻译.
- 生物标志物对于早期检测,风险分层和个性化OSCC治疗至关重要.
相关概念视频
02:57Targeted Cancer Therapies
8.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
8.6K
02:49Cancer Therapies
9.8K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
9.8K
02:38Mitogens and the Cell Cycle
7.7K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
7.7K
01:37Epigenetic Regulation
3.7K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.7K
02:18Cancer
53.5K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
53.5K