在死后血液中同时定量测定2--2-oxo-phenylcyclohexylethylamine,methylenedioxymethamphetamine和ketamine,使用液体染色学-并联质谱法

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Meejung Park¹, Sungmin Moon², Nahyun Lee³

¹Forensic Toxicology Division, National Forensic Service, 10, Ipchun-ro, Wonju-si, Kangwon-do, 26460, Republic of Korea. meejung@korea.kr.

Forensic toxicology

|October 2, 2025

概括

法医毒理学家现在可以使用一种新的验证方法在尸检中检测到2--2-oxo-PCE. 这种分析有助于理解涉及这种新兴分离性物质的致命中毒.

科学领域:

法医毒理学法医毒理学
分析化学分析化学
药理学药理学是指药理学的学科.

背景情况:

滥用新型分离性麻醉剂二二氧化-基环乙烯胺 (2F-2-oxo-PCE) 的情况正在上升.
这种物质在结构上与芬西克利丁 (PCP) 和胺相关.
在死后调查中需要可靠的检测方法.

研究的目的:

报告第一个法医毒理学检测2F-2-oxo-PCE在尸检的情况下.
开发和验证一种方法,用于在死后血液中同时定量2F-2-oxo-PCE和其他药物.
为解释2F-2-oxo-PCE相关死亡事故提供数据.

主要方法:

气色谱-质谱 (GC-MS) 用于初步识别2F-2-oxo-PCE及其代谢物.
液体染色学-并联质谱学 (LC-MS/MS) 结合固相提取 (SPE) 进行量化.
方法验证包括线性,准确性,精度,矩阵效应和回收.

主要成果:

对LC-MS/MS方法实现了令人满意的验证参数.
在死后的血液样本中检测到2F-2-oxo-PCE的度在664至7911 ng/mL之间.
与MDMA和胺同时检测表明在致命病例中可能使用多种药物.

结论:

经过验证的LC-MS/MS方法适用于法医应用.
这种方法可以提高新出现的分离性物质的毒理分析.
这些发现为了解2F-2-oxo-PCE相关中毒提供了必要的基线数据.

关键词:

2F-2-oxo-PCE是一种2F-2-oxo-PCE.胺基氨酸 (ketamine) 是一种可以这是LC-MS/MS.这是MDMA,MDMA.在死后进行尸检.

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