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在过去的几十年中,健康婴儿肠道微生物群的变化
Teo Oksanen1, Martina Baizán-Urgell2, Maria Carmen Collado2
1Department of Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Turku, Turku, Finland.
Neonatology
|October 2, 2025
概括
婴儿肠道微生物群的多样性几十年来一直在下降,Bifidobacterium细菌越来越少. 这一趋势与非传染性疾病风险的增加相关,突出显示了早期生命中潜在的微生物群影响.
科学领域:
- 微生物组研究的研究.
- 儿科卫生保健 儿科卫生保健
- 公共卫生趋势 公共卫生趋势
背景情况:
- 双杆菌是婴儿肠道健康的关键.
- 减少Bifidobacterium与非传染性疾病风险有关.
- 在过敏和肥胖流行病中调查婴儿肠道微生物群的变化.
研究的目的:
- 评估影响婴儿肠道微生物群组成的因素.
- 检查与公共卫生趋势有关的随时间变化.
- 确定肠道微生物群变化的关键决定因素.
主要方法:
- 在三个出生年份组 (1997-2022) 中分析了48名婴儿 (1-3个月大) 的便样本.
- 利用16S rRNA基因片序列为微生物群的概况.
- 考虑的围产因素:出生方式和抗生素暴露.
主要成果:
- 随着时间的推移,婴儿肠道微生物群的丰富性和多样性显著下降.
- 在出生较晚的婴儿 (2015-2022) 中减少了Actinobacteriota和Bifidobacterium的丰度.
- 出生时间是最重要的决定因素,其次是母亲的BMI和抗生素暴露.
结论:
- 肠道微生物群的丰富性和多样性在婴儿中有所下降.
- 已经发生了Bifidobacterium丰富性的选择性减少.
- 这些变化与非传染性疾病的增加并行.
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