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接种流感疫苗后皮下结节和脂瘤的风险增加:一个多中心的TrinetX队列研究

Neal Gupta, Alexia Collins, Kayla Zafar

Journal of drugs in dermatology : JDD

|October 2, 2025

概括

接种流感疫苗可能会增加患手臂皮下结节和脂瘤的风险. 适当的注射技术至关重要,以尽量减少流感疫苗接种后这些潜在的不良事件.

科学领域:

公共卫生公共卫生
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

流感疫苗接种是一个关键的公共卫生干预措施.
罕见的皮肤反应,如结节和可能发生,特别是在不当的管理.
临床观察表明肌肉内接种疫苗和脂瘤的发展之间存在联系.

研究的目的:

评估肌肉内流感疫苗接种后手臂上部皮下结节和脂质瘤的风险.
调查流感疫苗接种与局部皮肤反应之间的关联.

主要方法:

使用TriNetX平台进行了倾向分数匹配的队列分析.
在接种疫苗和未接种疫苗的人群中,手臂皮下结节和上臂脂瘤的风险比较.
针对潜在的混因素进行调整,以确保可靠的分析.

主要成果:

接种流感疫苗的个人显示手臂皮下结节的风险增加 (HR: 1.32,95% CI: 1.28-1.37).
在接种疫苗的人群中,观察到上臂脂瘤发展的风险较高 (HR: 1.57,95% CI: 1.28-1.93).

结论:

肌肉内接种流感疫苗与患上手臂上部皮下结核和脂质瘤的风险更高有关.
强调正确的疫苗注射技术的重要性,以减少不良事件.
这些发现支持对疫苗接种后局部反应保持警.

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