基于肠道微生物群的治疗对自闭症谱系障碍和注意力缺陷多动性障碍的有效性:系统性审查和元分析
Weijie Sun1,2,3, Liang Ma3, Xiangnan Feng3
1Department of Psychiatry, Chaohu Hospital of Anhui Medical University, Hefei, Anhui, China.
Psychology, health & medicine
|October 2, 2025
概括
肠-大脑轴干预显示,对神经发育障碍,如自闭症谱系障碍 (ASD) 和注意力缺陷多动性障碍 (ADHD) 具有小但显著的益处. 经过8周的干预观察到最优的结果,表明有前途的辅助疗法.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 肠-大脑轴是神经发育状况治疗发展的关键区域.
- 对于自闭症谱系障碍 (ASD) 和注意力缺陷多动性障碍 (ADHD) 的肠道微生物干预措施的有效性需要进一步澄清.
研究的目的:
- 对ASD和ADHD肠道微生物干预的随机对照试验 (RCT) 进行系统的审查和元分析.
- 综合这些干预措施的有效性,安全性和最佳持续时间的证据.
主要方法:
- 按照PRISMA 2020指南进行系统审查和元分析.
- 搜索了多个RCT数据库,包括益生菌,益生菌,饮食变化和便移植.
- 使用随机效应模型进行聚合分析,以评估整体和疾病特异性影响.
主要成果:
- 在肠道微生物群干预方面发现了小但显著的整体益处 (SMD = -0.12).
- 注意缺陷多动性障碍 (ADHD) 显示出比自闭症谱系障碍 (ASD) (SMD = -0.05) 更大的改善 (SMD = -0.24).
- 八周的干预表明了显著的结果,与可比的中断率和没有严重的不良事件报告.
结论:
- 肠道微生物组调节似乎是神经发育障碍,特别是ADHD的安全辅助疗法.
- 最佳的干预持续时间约为8周,但证据仍然是初步的.
- 未来的研究需要大规模的RCT与标准化的协议建立临床指导方针.
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