多指纹症和癌症风险 多指纹症和癌症风险
Matthew V Abola1, Logan M Good2,3,4, Kira L Smith2,3,4
1Hospital for Special Surgery, New York, NY.
Journal of pediatric orthopedics
|October 2, 2025
概括
非综合性多样性肌痛症与儿童良性瘤发病率较高有关. 然而,与对照组相比,这些患者的骨,软骨和乳腺癌风险较低.
科学领域:
- 儿科瘤学 儿科瘤学
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 综合性多节节症与癌症风险增加有关.
- 有限的数据存在于非综合征多肢症的癌症风险.
- 这项研究调查了小儿非综合症多样性瘤的发病率.
研究的目的:
- 为了比较患有非综合征性多肢症的儿科患者的瘤发病率与匹配的对照人群.
- 为了确定非综合征性多样性肌肉病和随后的恶性瘤之间的潜在关联.
- 分析与非综合征性多肢性结合症相关的特定部位癌症风险.
主要方法:
- 使用TrinetX美国协作网络数据库进行回顾性队列研究.
- 使用ICD-9/ICD-10代码识别了患有多爪病的儿科患者 (≤10岁).
- 倾向性匹配了14361名患有多肢症的患者与14361名对照人进行比较.
主要成果:
- 聚达症队列显示任何瘤 (3.3%对2.6%) 和良性瘤 (2.6%对2.2%) 的比率显著更高.
- 在队列之间没有观察到恶性瘤总体发病率的显著差异.
- 骨,软骨和乳房的恶性瘤在多节节症队列中明显较低.
结论:
- 非综合性多肢症与瘤的发病率增加有关,特别是良性类型.
- 骨,软骨和乳腺的特定部位癌症在患有多节节症的患者中减少.
- 需要进一步的研究,以了解多节点病与癌症风险之间的复杂关系.
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