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Updated: Jan 16, 2026

07:22
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
9.3K
[儿科中不过敏的Brentuximab vedotin立即过敏:皮肤测试的有用性以指导挑测试]
Karla Daniela González-Silva1, Pablo Perea-Valle1, José Alonso Gutiérrez-Hernández1
1Hospital Infantil de México Federic Gómez, ciudad de México.
概括
对布伦图西马布维多丁 (BV) 的过敏反应可能发生在霍奇金淋巴瘤患者中. 脱敏使儿科患者能够在过敏反应后安全地继续基本的BV治疗.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 对单克隆抗体的过敏反应带来了挑战,特别是当没有替代品存在时.
- 布伦图西马布维多丁 (BV) 是一种抗CD30抗体,用于治疗复发的霍奇金淋巴瘤,并可能导致立即过敏 (1.2%的病例).
研究的目的:
- 在患有复发性霍奇金淋巴瘤的儿科患者中报告对布伦图西马布维多丁严重过敏的病例.
- 评估继续治疗BV的脱敏方案的安全性和有效性.
主要方法:
- 一名11岁的患者在BV化疗期间经历了3级过敏反应.
- 皮肤BV测试呈阴性;然而,在两个周期内进行了脱敏.
- 患者接受了AVD化疗剂加BV,在脱敏后没有任何不良反应.
主要成果:
- 患者耐受了两次布伦图西马布维多丁脱敏疗程,而过敏症没有复发.
- 观察到阴性BV皮肤测试,但临床表现表明非过敏过敏.
- 实现了布伦图西马布维多丁治疗的延续.
结论:
- 脱敏感化是一种有效的策略,可以在患有过敏症的儿科瘤患者中继续进行基本治疗.
- 虽然皮肤测试可以提供支持,但脱敏可以安全地继续布伦图西马布维多丁治疗.
- 对于安全性评估,应考虑对重复皮肤测试和挑战测试进行进一步评估.
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