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跨性别和性别多样性患者在性别确认顶部手术中对遗传性乳腺癌风险评估的观点

Kimberly Zayhowski^1,2, Kai Blumen³, Kathleen F Mittendorf^4,5

¹Department of Obstetrics and Gynecology, Boston University Chobanian and Avedisian School of Medicine, Boston, MA.

JCO precision oncology

|October 2, 2025

概括

变性人和性别多样的人在顶部手术后进行乳腺癌查时面临挑战. 将遗传风险评估纳入性别肯定护理可以改善查和手术决策.

科学领域:

在瘤学瘤学.
跨性别者健康跨性别者健康
遗传学遗传学是一个

背景情况:

变性人和性别多元 (TGD) 个体经历更高的癌症风险.
目前乳腺癌指导方针不充分解决性别确认手术 (顶部手术).
建议进行手术前遗传风险评估,但没有标准化.

研究的目的:

探索接受顶部手术的TGD患者乳腺癌风险评估和查的障碍和促进因素.
了解手术前遗传评估的有用性和可接受性.

主要方法:

定性社区参与的研究.
对16名TGD成年人进行了深度采访,他们计划或曾经接受过顶部手术.
反思性的专题分析.

主要成果:

关于顶部手术后癌症查的不确定性.
缺乏提供者知识和女性化的乳腺健康空间造成了障碍.
将美学目标与降低癌症风险之间的平衡是关键.
减少失调症可以增加查舒适度.
渴望获得综合癌症遗传学服务.

结论:

需要可行的指导来改善TGD个体的乳腺癌健康公平.
加强患者教育,提供者意识和包容性指南.
变性健康空间,并将遗传学纳入跨性别护理途径.

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