在患有囊性纤维化患者的怀孕
Beth L Pineles1, Raksha Jain, Traci M Kazmerski
1Division of Maternal-Fetal Medicine and the Division of Pregnancy Loss and Comprehensive Family Planning, Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, and the Department of Pediatrics, University of Pittsburgh School of Medicine, and the Center for Innovative Research on Gender Health Equity (CONVERGE), University of Pittsburgh, Pittsburgh, Pennsylvania; the Division of Pulmonary and Critical Care, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; the Division of Pulmonary Sciences and Critical Care Medicine and Pediatric Pulmonology, Department of Medicine and Pediatrics, National Jewish Health, Denver, and the Departments of Internal Medicine and Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado; the Department of Pediatrics, University of California, San Diego, San Diego, California; and the Division of Genetic Counseling and the Division of Pediatric Pulmonology, Allergy & Immunology, Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina.
囊性纤维化 (CF) 越来越多地影响成年人,新的CFTR调节器改善了结果并增加了怀孕率. 仔细的计划生育,包括避孕和预孕咨询,对于患有CF的人来说至关重要.
科学领域:
- 医学遗传学 医学遗传学
- 肺部病理学 肺部病理学
- 生殖健康 生殖健康
背景情况:
- 囊性纤维化 (CF) 是一种影响所有人群的遗传性疾病.
- 现在,成年人占CF患者的大多数,预期寿命增加.
- 在CF护理和CFTR调节器方面的进步改善了结局和生育能力.
研究的目的:
- 在CFTR调节器时代,审查CF患者的计划生育考虑因素.
- 强调怀孕前咨询和母胎医学专业知识的重要性.
- 讨论新的产前检测和移植性药物转移的影响.
主要方法:
- 关于CF护理,CFTR调节器和CF的生殖健康的最新进展的文献综述.
- 对CF患者的避孕,预孕,怀孕和母乳养的当前建议的综合.
- 讨论新兴技术,如胎儿CF的非侵入性产前检测.
主要成果:
- CFTR调节器显著改善了CF患者的健康状况,并增加了CF妇女的怀孕率.
- 怀孕前咨询非常重要,因为怀孕期间CF患者的风险增加.
- 鼓励母乳养,并对婴儿进行潜在副作用监测.
- 胎儿CF的非侵入性产前检测正在出现,从子宫内暴露于CFTR调节器的潜在好处.
结论:
- 患有CF的人需要全面的计划生育策略,包括避孕和孕前护理.
- CFTR调节器在胎儿发育中的作用需要进一步研究.
- 在现代治疗环境中,持续的研究对于了解CF患者的怀孕和育儿是必不可少的.
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