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Updated: Jan 16, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
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一种多功能合成方法,用于各种5-基改性异酸衍生物:细胞毒性,乙胆酶抑制活性和分子建模研究

Kirill P Cheremnykh1, Igor D Ivanov2, Mohammad S Hamad3

  • 1N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Academician Lavrentyev Ave, 9, 630090 Novosibirsk, Russian Federation; The Federal Research Center Insitute of Molecular Biology and Biophysics, 2/12, Timakov St., 630117 Novosibirsk, Russian Federation.

Bioorganic chemistry
|October 2, 2025
PubMed
概括

新的伊萨衍生物显示出强大的抗癌活性和乙胆酶抑制. 这些化合物对各种癌症细胞系具有显著的细胞毒性,对正常细胞的毒性较低,表明具有治疗潜力.

关键词:
A3 - 合反应乙烯基胆化酶抑制剂的使用细胞毒性 细胞毒性印度醇-1H-2,3-二子异氨酸 是一种异氨酸.分子对接研究分子对接研究索诺加希拉的反应

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