对气体/化学动力学增强免疫治疗的免疫抑制微环境的依赖性重塑
Shu-Lan Li1, Meng-Die Duan1, Guo-Dong Cheng2
1State Key Laboratory of Advanced Separation Membrane Materials, School of Chemical Engineering and Technology & School of Chemistry, Tiangong University, Tianjin 300387, PR China.
Journal of colloid and interface science
|October 2, 2025
概括
状铜纳米集群 (Cu CDs) 重塑瘤微环境以增强免疫疗法. D-Cu CDs有效地向瘤细胞,破坏免疫抑制,并激活免疫反应以产生强大的抗瘤作用.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 免疫治疗是一种免疫疗法.
背景情况:
- 瘤微环境 (TME) 通常会抑制抗瘤免疫力.
- 开发重新设计TME的策略对于有效的癌症治疗至关重要.
研究的目的:
- 设计一种性纳米系统 (L-/D-Cu CDs),具有多酶类和无生成活动.
- 研究Cu CDs与增强免疫治疗的生物系统的依赖于性相互作用.
主要方法:
- 合成具有多酶类和NO生成活动的L-/D-Cu CDs.
- 评估CD47受体结合亲和力和内部化通过克拉特林介导的内细胞化.
- 评估TME调节,包括反应性氧物种 (ROS) 和氧化 (NO) 生成,缺氧缓解和巨细胞再极化 (M2到M1).
- 在体外和体内研究以证实免疫刺激功效和瘤抑制.
主要成果:
- D-Cu CDs对CD47的结合亲和力更高,促进了内部化.
- D-Cu CDs有效地破坏了氧化还原和铜平衡,缓解了TME缺氧,并诱导了瘤细胞亡和亡.
- 巨细胞成功地从M2复极化到M1表型,增强了免疫反应.
- 证明了显著的免疫刺激功效和瘤抑制在体外和体内.
结论:
- 化CD可以有效地重塑免疫抑制性TME.
- D-Cu CDs为气体/化学动力学增强免疫疗法提供了一个有希望的策略.
- 这项工作为癌症治疗中的奇拉纳米材料应用提供了新的见解.
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