精神分裂症谱系障碍中的认知代谢特征:系统性审查
Kristoffer J Panganiban1, Emily C C Smith1, Nicolette Stogios1
1Schizophrenia Division, Centre for Addiction and Mental Health, Toronto, ON M6J 1H3, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, M5T 1R8, Canada.
Psychiatry research
|October 2, 2025
概括
这项系统性审查在精神分裂症谱系障碍 (SSD) 和认知障碍患者中发现了44种失调的代谢物. 这些发现突出了未来针对SSD认知缺陷的治疗方法的潜在途径.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生化学
- 精神病学是一个精神病学.
背景情况:
- 代谢资料提供了对精神分裂症谱系障碍 (SSD) 机制的见解.
- 认知障碍是SSD的一个核心症状.
- 研究与认知功能相关的代谢变化可能会揭示新的治疗点.
研究的目的:
- 系统地审查和检查SSD中的代谢特征和认知障碍之间的关联.
- 在SSD中识别特定的代谢物和代谢途径,与认知功能障碍有关.
- 解决目前关于这个话题的系统审查缺口.
主要方法:
- 在Ovid MEDLINE,EMBASE和Scopus中系统地搜索数据库.
- 纳入标准集中在"精神分裂症谱系障碍"",代谢学"和"认知"的研究,并进行病例控制或关联分析.
- 使用约翰娜·布里格斯研究所的批判性评估工具评估偏差风险.
主要成果:
- 纳入了9项研究,在认知障碍SSD患者中确定了44种失调的代谢物.
- 38种代谢物被降低调节,6种被上调调节.
- 碳氧酸,有机氧化合物和脂肪酸常常是失调的类别;甘油脂,甘油脂和脂肪酸与认知有混合关联.
结论:
- 已识别的代谢物可能会影响涉及炎症,谷氨酸/谷氨胺代谢和脂质代谢的途径.
- 这些代谢途径可能在SSD中观察到的认知障碍中发挥作用.
- 研究结果表明,SSD中认知缺陷的潜在生物标志物和治疗点.
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