潜在的下一代目标,用于抗菌剂的发现和开发
Pooja Gupta1, Pushplata Yadav2, Manjul Lata2
1Molecular Microbiology and Immunology Division, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow, 226031, Uttar Pradesh, India; Jawaharlal Nehru University, New Mehrauli Road, JNU Ring Road, New Delhi, 110067, India.
European journal of medicinal chemistry
|October 2, 2025
概括
抗生素耐药性是一个全球危机,威胁着后抗生素时代. 本次审查确定了28种新型抗菌点和分子,以加快新药的开发.
科学领域:
- 微生物学与传染病的研究
- 药物发现和开发 药物发现和开发
- 公共卫生 公共卫生
背景情况:
- 抗微生物药物耐药性 (AMR) 是一个严重的全球卫生危机,由不适当的抗微生物药物使用和演变驱动.
- 新抗生素的管道非常低,几乎没有新的作用机制,将医学推向后抗生素时代.
- 现有的候选药物通常会失败,因为它们是当前抗生素的衍生品或已经表现出耐药性的向途径.
研究的目的:
- 通过确定尚未探索的目标来解决对新型抗菌剂的迫切需求.
- 审查最近发现的具有抗菌活性的分子及其潜在目标.
- 为协调药物开发和降低下一代抗生素消耗率提供战略.
主要方法:
- 对过去五年的科学出版物进行了全面的文献审查.
- 识别和总结可行的,尚未探索的抗菌点.
- 对新型抗菌分子及其作用机制的分析.
主要成果:
- 确定了28个可行的尚未探索的目标,用于开发新型抗菌药物.
- 编制了最近文献中报告的新型抗菌分子及其潜在点的清单.
- 对抗菌药物开发中的关键挑战,缺口和战略方法的概述.
结论:
- 迫切需要新的抗微生物药物,具有新的机制,以应对抗微生物药物耐药性日益增长的威胁.
- 已识别的点和分子为开发安全,有效和负担得起的抗菌药物提供了基础.
- 重新审视开发策略和协调程序可以加快新一代抗生素的开发,减轻抗菌药物耐药性危机.
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