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解读氏甲在质母细胞瘤中的致癌作用:来自网络毒理学,单细胞转录组学和门德尔随机化的洞察

Liye Yi¹, Wencai Wang¹, Zhonghua Sun²

¹The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China.

Ecotoxicology and environmental safety

|October 2, 2025

概括

[a]烯 (BaP) 可能通过向TP53基因促进质母细胞瘤 (GBM). 这项研究揭示了GBM发展的潜在机制,并提出了新的治疗途径.

科学领域:

环境毒理学环境毒理学
癌症基因组学癌症基因组学
网络药理学网络药理学

背景情况:

甲 (BaP) 是一种环境致癌物,与质母细胞瘤 (GBM) 的联系尚不清楚.
研究BaP在GBM发病过程中的作用对于理解和治疗这种侵袭性脑瘤至关重要.

研究的目的:

阐明BaP对GBM瘤发生有所贡献的分子机制.
为了确定关键的基因和涉及到BaP诱导的GBM的途径.

主要方法:

综合分析使用网络毒理学,单细胞转录组学,孟德尔随机化 (MR) 和文献分析.
预测BaP目标基因和检索GBM相关基因,然后进行网络构建和分子模拟.
通过体外实验验证发现,并分析单细胞RNA测序数据.

主要成果:

确定了31个重叠基因,TP53在恶性GBM细胞和免疫细胞中显著表达.
核磁共振分析显示TP53表达和GBM风险之间存在显著的反向关联.
分子对接和模拟证实了BaP和TP53之间强大的结合,通过体外实验验证实了这一点.

结论:

[a]烯 (BaP) 可能通过向瘤抑制基因TP53.3来驱动质母细胞瘤 (GBM) 的发展.
这项研究为GBM中BaP的致癌机制提供了新的见解,表明TP53是预防和治疗的潜在治疗标.

关键词:

子[a]二烯是一种二烯.图书统计学分析质母细胞瘤 (glioblastoma) 是一个门德尔的随机化网络毒理学网络毒理学单细胞转录组学单细胞转录组学

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