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使用微生物外聚糖的金属纳米制造方面的进展:新兴的生物医学应用

Kumar Manimaran¹, Thammasak Rojviroon², Orawan Rojviroon²

¹Department of Materials and Metallurgical Engineering, Faculty of Engineering, Rajamangala University of Technology Thanyaburi, Pathum Thani 12110, Thailand.

International journal of pharmaceutics

|October 2, 2025

概括

自然外聚糖 (EPS) 提供了一种可持续的方法来制造金属纳米粒子 (NP). 这些EPS介导的NP显示出作为环保抗癌和抗菌剂的巨大潜力,解决耐药性挑战.

科学领域:

生物技术和纳米医学
材料科学材料科学材料科学

背景情况:

越来越多的人对基于天然多糖的纳米颗粒 (NP) 感兴趣,因为它们的生态友好,成本效益和安全生产.
外聚糖 (EPS) 是多功能生物聚合物,在包括食品,制药和化品在内的各种行业都有应用.
癌症和微生物疾病中耐药性的威胁日益增加,需要新的治疗替代方案.

研究的目的:

为提取和净化外聚糖 (EPS) 提供全面的方法.
用细菌EPS作为绿色基质探索金属纳米颗粒 (NP) 的合成和表征.
研究EPS介导NP作为抗癌和抗菌剂的潜力.

主要方法:

选和发酵优化用于EPS生产.
预处理,去除蛋白质,沉和净化EPS.
通过EPS介导的金属纳米粒子 (例如,Ag,Au,Zn,Ti) 的绿色合成,然后进行表征.

主要成果:

EPS 具有聚离子功能组,可以有效地减少和稳定金属NP.
通过EPS介导的NP对各种癌症类型和致病细菌表现出广泛的抗癌和抗微生物活性.
该研究详细介绍了EPS提取,EPS介导NP的绿色合成及其表征.

结论:

由EPS制造的纳米粒子是生物相容,可生物降解,无毒和可持续的,因此它们非常适合纳米技术和医疗应用.
以EPS为媒介的金属NP为癌症和微生物感染的传统疗法提供了一个有希望的替代方案.
这项研究突出了基于EPS的纳米材料对未来治疗发展的潜力.

关键词:

具有抗菌活性,具有抗菌活性.这是一种抗癌药物.细菌细菌是一种细菌.在外聚糖类中,含有外聚糖类.绿色合成是一种绿色合成.纳米颗粒纳米颗粒

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