反向工程专用肠道营养作为儿童克朗病的诱导疗法:对环境毒素暴露的影响
Elizabeth A Reznikov1, Melissa M Melough2, Dale Y Lee1
1Department of Pediatrics, Division of Gastroenterology, Seattle Children's Hospital and University of Washington, Seattle, WA, USA.
概括
这项试点研究发现,全食 Smoothie 饮食 (RE-EEN) 显著减少了儿童克罗恩病患者的重金属暴露. 这种饮食还在诱导临床缓解方面表现有希望,这表明减少环境毒素和改善疾病结果之间的联系.
科学领域:
- 环境健康 环境健康
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 独家肠道营养 (EEN) 对于克罗恩病 (CD) 缓解是有效的.
- 商业EEN配方含有添加剂;开发了一种全食品替代品 (RE-EEN).
- 据假设,RE-EEN可以减少环境毒素的暴露.
研究的目的:
- 评估RE-EEN对小便重金属和毒素水平在儿科CD患者的影响.
- 评估RE-EEN,环境毒素暴露和临床缓解之间的关系.
主要方法:
- 试点研究涉及儿童CD患者进行为期四周的RE-EEN干预.
- 在基线和第2,4,8周收集的生物样本.
- 用质谱学分析尿液中的重金属,酸盐和胺.
主要成果:
- 到第四周,尿道的显著减少 (83%) 和的建议减少 (77%).
- 在分析所有周时,和水平仍然显著.
- 没有观察到甲酸盐或胺水平的显著变化.
结论:
- RE-EEN的饮食干预措施显示了减少儿科CD中环境毒素暴露的潜力.
- 在重金属中观察到的变化表明对有毒物质负担有有利影响.
- 需要进一步研究更大的样本大小和对照组来证实研究结果.
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