即使较低的酒精摄入量也可能对东亚男性具有MASLD频谱有害
Byungyoon Yun1, Juyeon Oh2, Heejoo Park2
1Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; The Institute for Occupational Health, Yonsei University College of Medicine, Seoul, Republic of Korea; The Institute for Innovation in Digital Healthcare, Yonsei University Health System, Seoul, Republic of Korea.
概括
东亚男性患有代谢功能障碍相关的脂肪性肝病 (MASLD) 面临较高的肝脏相关事件 (LRE) 风险,酒精摄入量低于此前推的水平. 新的,特定于种族的酒精指南对于预防该人口中的LREs至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 对于MASLD的标准酒精指南可能不适用于东亚人,原因是遗传因素,如ALDH2变异.
- 这些变体增加了酒精敏感性和肝损伤的风险.
研究的目的:
- 在东亚男性患有MASLD时,确定与肝脏相关事件 (LREs) 的特定种族的酒精消费门.
- 为MASLD管理提供文化敏感的公共卫生建议.
主要方法:
- 一项全国性的韩国队列研究,包括1,087,803名患有MASLD的男性 (年龄≥40岁).
- 酒精摄入量被分类为每周;LREs (肝癌,肝硬化,肝脏死亡率) 被追踪了11年.
- 考克斯的比例危险模型和受限立方线分析评估了酒精和LRE风险关系.
主要成果:
- 与没有酒精相比,在每周140-210克 (aHR 1.10) 和≥210克 (aHR 1.30) 的LRE风险增加.
- 易受伤害的子组 (糖尿病,低BMI,高ALT) 在更低的值 (每周70-140克) 显示风险增加.
- 确认了酒精和LRE风险之间的J形,非线性剂量反应关系.
结论:
- 东亚男性有MASLD经验,在酒精消费水平低于当前欧洲/北美指导方针时,LRE风险较高.
- 制定特定种族的酒精建议对于预防这一人口群体的LREs至关重要.
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