在稳定的COPD患者中评估微量营养素
Turan Onur1, Sarıoglu Nurhan2, Turan Pakize Ayse3
1Department of Chest Diseases, Izmir Katip Celebi University, Atatürk Research and Training Hospital, Izmir, Turkey.
微量营养素缺乏,包括维生素D,B-12和叶酸,在慢性阻塞性肺病 (COPD) 患者中很常见. 低维生素D水平与COPD的疾病严重程度和生活质量降低有关.
科学领域:
- 肺部病理学 肺部病理学
- 营养科学 营养科学
- 临床医学 临床医学
背景情况:
- 慢性阻塞性肺病 (COPD) 与营养不良,代谢和炎症有关.
- 这些因素增加了COPD患者维生素缺乏的可能性.
研究的目的:
- 评估稳定的COPD患者中维生素D,B-12和叶酸缺乏症的患病率.
- 调查这些缺陷与临床参数之间的关系.
主要方法:
- 招募了168名COPD患者和36名健康对照.
- 血清维生素B-12和叶酸水平通过化学发光免疫测试 (CLIA) 进行测量.
- 使用高性能液态染色学 (HPLC) 确定了血25-OH D3水平.
主要成果:
- 在COPD患者中,缺乏维生素D (68.9%),维生素B-12 (21.7%) 和叶酸 (50%) 的高患病率.
- 与对照组相比,COPD患者的维生素D水平显著降低 (68.9%与16.6%,p <0.001).
- 低维生素D与更高的年龄,加剧的恶化和更差的生活质量相关 (SGRQ影响评分).
结论:
- 维生素D,B-12和叶酸缺乏在慢性慢性病中很常见.
- 低维生素D与疾病严重程度和生活质量下降有关.
- 对COPD中微量营养素补充的进一步研究是有必要的.
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