在有抑郁症状的老年人中,结构功能连接性合的改变
Ting Li1,2, Haishuo Xia3, Shaokun Zhao4
1State Key Laboratory of Cognitive Neuroscience and Learning, https://ror.org/022k4wk35Beijing Normal University, Beijing, China.
患有抑郁症的老年人表现出大脑连接的改变,特别是在注意力和皮质下网络. 这些结构功能连接 (SFC) 变化因代谢疾病和睡眠障碍等健康状况而异.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 精神病学是一个精神病学.
背景情况:
- 老年人的抑郁症状与受损的大脑网络有关.
- 改变结构功能连接 (SFC) 在老年抑郁症的影响尚不清楚.
- 考虑到生理相关疾病,对患有抑郁症的老年人进行SFC改变的调查至关重要.
研究的目的:
- 为了研究老年人抑郁症状的结构功能连接合 (SFC) 的变化.
- 探索这些SFC变化是如何根据生理伴随性疾病的存在而有所不同.
- 在老年人中确定个性化抑郁干预的潜在神经标志物.
主要方法:
- 利用了415名患有抑郁症状的老年人和415名年龄相匹配的对照者的多式神经成像数据 (dMRI/rs-fMRI).
- 根据相关疾病,在抑郁组内建立了已确定的子组:高血压,高脂血症,糖尿病,脑血管疾病和睡眠障碍.
- 检查了SFC中的组和子组差异,并跟踪了与症状进展相关的变化.
主要成果:
- 与对照人群相比,患有抑郁症状的老年人在腹部注意网络中显著增加了SFC.
- 在皮下网络,特别是左桃体内的SFC变化与抑郁症状进展相关.
- 亚组分析揭示了异质的SFC变化,与不同的神经机制相关的代谢疾病和睡眠障碍.
结论:
- 在患有抑郁症的老年人中,在腹部注意力和皮层下网络内确定了SFC的显著变化.
- 突出了与代谢疾病和睡眠障碍相关的异质SFC变化,强调了并发症的作用.
- 建议SFC变化可以作为个性化干预措施的潜在生物标志物,以改善老年人抑郁症的管理.
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