在COVID-19大流行期间监测维生素D水平的变化,使用例行收集的实验室数据
Lea Skapetze1,2, Daniela Koller1, Andreas Zwergal3,4
1Institute for Medical Information Processing, Biometry, and Epidemiology, Faculty of Medicine, LMU Munich, Munich, Germany.
Nature communications
|October 2, 2025
概括
随着COVID-19大流行,维生素D水平下降,缺乏率增加,特别是在老年妇女中. 需要公共卫生战略来监测和改善在有限的户外活动期间维生素D状态.
科学领域:
- 营养科学 营养科学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 维生素D对骨健康和免疫功能至关重要.
- 随着COVID-19大流行,导致封锁和减少户外活动,引发了人们对维生素D水平的担忧.
- 饮食改变和有限的阳光照射可能会影响维生素D状态.
研究的目的:
- 评估COVID-19大流行之前和期间维生素D水平和缺乏率的变化.
- 用例行收集的实验室数据分析大量患者队列中的趋势.
- 为了确定受维生素D状况变化影响最大的人口群体.
主要方法:
- 分析了德国巴伐利亚州292,187名患者的实验室数据.
- 在大流行前 (2018年3月至2020年2月) 和大流行 (2020年3月至2022年2月) 期间,维生素D水平的比较.
- 描述性统计,倾向性得分匹配和因果森林的应用,用于混调整分析.
主要成果:
- 平均维生素D水平显著下降,从26.7微克/升降至26.0微克/升 (p < 0.001).
- 维生素D缺乏率从31.2%增加到35.2% (p < 0.001).
- 老年妇女的维生素D水平下降最明显,缺乏率增加.
结论:
- COVID-19大流行与维生素D水平的显著下降和缺乏症的增加有关.
- 公共卫生干预对于监测和增强维生素D状态至关重要,特别是在限制户外活动期间.
- 针对老年妇女等弱势群体可能需要有针对性的战略.
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