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Updated: Jan 16, 2026

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay EMSA and DNA-affinity Precipitation Assay DAPA
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跨eQTL映射优先考虑USP18作为狼风险位的干扰素反应的负调节器

Krista Freimann1,2, Anneke Brümmer3,4, Robert Warmerdam5,6

  • 1Institute of Computer Science, University of Tartu, Tartu, Estonia.

Nature communications
|October 2, 2025
PubMed
概括

这项研究通过分析跨表达量化特征位点 (trans-eQTL) 数据,确定了影响复杂特征的遗传位点. 一项关键发现将USP18基因与系统性红斑狼 (SLE) 风险联系起来,通过影响干扰素信号传递.

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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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