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Updated: Jan 16, 2026

Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta
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Functional Characterization of RING-Type E3 Ubiquitin Ligases In Vitro and In Planta

Published on: December 5, 2019

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RNF114和RNF166是阅读-写 E3 连接酶的例子,这些连接酶将K11 聚尤比基因扩展到MARUbylation的部位上

Rachel E Lacoursiere1, Kapil Upadhyaya2, Jasleen Kaur Sidhu1

  • 1Department of Molecular Microbiology and Immunology, Oregon Health & Science University, Portland, OR, 97239, USA.

The EMBO journal
|October 2, 2025
PubMed
概括

德莱克斯DTX2在PARP7上结合了ADP-ribose (ADPr) 修饰,而RNF114则通过K11结合的多比基因扩展了这一功能. RNF114通过一个新的M-UBD域识别这些单个ADPr-Ub Ester (MARUbe),识别MARUbe向性结合酶 (M-UTLs).

关键词:
在ADP-ribose Ubiquitylation中使用.K11 聚聚化化在PARP/Ubiquitin的交叉结构中.翻译后修改 翻译后修改

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