在三阴性乳腺癌中程序化的细胞死亡
Yaqi Liu1, Jinwei He1, Jialu Chen1
1School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuan, People's Republic of China.
Cellular & molecular biology letters
|October 2, 2025
概括
三重阴性乳腺癌 (TNBC) 治疗是具有挑战性的,因为缺乏目标. 本综述探讨了编程细胞死亡 (PCD) 途径,如新型组合疗法和TNBC中改进免疫疗法的亡和铁亡.
科学领域:
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- 三阴性乳腺癌 (TNBC) 是一种具有攻击性的亚型,缺乏标准的治疗点.
- 由于TNBC对传统治疗的耐药性,因此需要新的治疗策略.
- 编程细胞死亡 (PCD) 途径越来越多地被认为是它们在癌症进展和治疗反应中的作用.
研究的目的:
- 审查TNBC中各种PCD途径的机制功能和治疗影响.
- 提出一个框架,利用相互连接的PCD途径进行有针对性的干预.
- 分析PCD和免疫疗法之间的交叉,以寻找协同效应的治疗方式.
主要方法:
- 在TNBC中对编程细胞死亡途径 (亡,烧亡,亡,自,铁亡) 的综合文献综述.
- 分析这些途径的机械功能,相互关系和治疗潜力.
- 检查PCD和基于免疫的疗法之间的相互作用.
主要成果:
- PCD路径表现出与共享的调解器和诸如炎症和线粒体功能障碍等特征的复杂相互联系.
- 针对这些相互连接的途径为组合和协同治疗策略提供了机会.
- PCD路径与免疫治疗结果高度相关,建议结合治疗方法.
结论:
- 一个集成的PCD路径网络为TNBC的新针对性干预提供了基础.
- 调节PCD路径可以放大治疗疗效,增强对免疫治疗的反应.
- 克服瘤多样性和耐药性等挑战对于这些策略的临床转化至关重要.
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