相关实验视频

Updated: Jan 16, 2026

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Determination of Biofilm Initiation on Virus-infected Cells by Bacteria and Fungi

Published on: July 6, 2016

在人类免疫缺陷病毒感染的不同阶段的唾液菌群多样性

Lu Lin^1,2, Wenshan Duan³, Yixi Yu²

¹Department of Prosthodontics, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, 100070, China.

BMC microbiology

|October 2, 2025

概括

口腔菌群的多样性随着艾滋病毒的进展而下降,而Candida在后期阶段显著增加. 某些真菌,如Debaryomyces和Talaromyces与艾滋病毒/艾滋病感染者免疫力改善相关.

科学领域:

口腔真菌学口腔真菌学
人类免疫缺陷病毒 (HIV) 研究研究
微生物组研究微生物组研究

背景情况:

口腔真菌感染在感染艾滋病毒/艾滋病的人群中很常见 (PLWHA).
关于艾滋病毒感染期间口腔真菌生物组变化的研究有限.
了解这些变化对于管理机会性感染至关重要.

研究的目的:

在PLWHA中分析口腔菌群多样性和组成.
为了比较艾滋病毒感染不同阶段的真菌生物组.
调查真菌生物和免疫标记物 (CD4+ T细胞计数,HIV病毒载量) 之间的相关性.

主要方法:

收集了63名艾滋病毒感染者 (0-3期) 和24名艾滋病毒阴性对照者的唾液样本.
使用内部转录间隔器 (ITS) 测序进行菌群分析.
与CD4+T细胞计数和HIV血液病毒载荷 (BVL) 相关联的真菌属丰富度.

主要成果:

口腔菌群α多样性随着艾滋病毒的发病阶段逐渐减少,在第3阶段最低.
与对照组相比,在HIV第一,第二和第三阶段,Candida的丰度显著增加.
德巴里奥美克斯和塔拉罗美克斯与CD4+T细胞计数呈正相关;Penicillium与BVL呈负相关.

结论:

口腔真菌微生态随着艾滋病毒的进展而动态变化.
在第三阶段增加的Candida和减少的非主导真菌可能会导致机会性感染.
特定的真菌属可能在HIV感染期间在免疫调节中发挥作用.

关键词:

CD4+ T 细胞的数量多样性多样性多样性多样性这就是我的mycobiome.在PLWHAHA中使用.这是唾液.

更多相关视频

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Author Spotlight: Oral Candida Diagnosis to Advance Clinical Treatment Regimen for pSS Patients

Published on: March 1, 2024

相关概念视频

Salivary Glands and Saliva

Salivary Glands and Saliva

The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...

Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency...