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Updated: Jan 16, 2026

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在铁灭过程中,RSL3通过不同的机制促进PARP1的亡功能

Dejian Chen1,2, Fei Xie3, Yimei Mo2

  • 1Wenzhou Key Laboratory of Cancer Pathogenesis and Translation, Key Laboratory of Laboratory Medicine, School of Laboratory Medicine and Life Sciences, Ministry of Education, Wenzhou Medical University, Wenzhou, 325035, Zhejiang, China.

Cellular & molecular biology letters
|October 2, 2025
PubMed
概括

铁亡激活剂RSL3通过Poly (ADP-ribose) 聚合酶1 (PARP1) 调节诱导了亡,提供了新的治疗途径. 这种机制即使在耐PARP抑制剂的癌症中也是有效的.

关键词:
N6 - - 甲基氨胺细胞灭亡 (apoptosis) 是一种死亡的过程.PARP1 的第一部分.耐PARPi的瘤是具有耐性的.在RSL3中使用RSL3.

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