非肌肉侵入性膀癌中的尿道微生物群:样本类型和性别差异的影响
Chaeeun Kang1,2, Junghoon Lee3, Min-Gyung Baek4
1Integrated Biomedical and Life Science, Graduate School, Korea University, Seoul, Korea.
BMC microbiology
|October 2, 2025
概括
导管尿液是研究癌症患者膀微生物群的最可靠样本. 细菌Curvibacter可能与膀癌的严重程度有关,这表明其作为生物标志物的潜力.
科学领域:
- 微生物组研究的研究.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
背景情况:
- 之前对膀癌患者的尿路微生物组研究中不一致的发现需要进一步调查.
- 这项研究解决了在膀癌中对微生物组失生症进行全面分析的需要.
- 它包含多种样本类型,负对照和基于性别的变异评估.
研究的目的:
- 在膀癌患者中分析微生物组失生症.
- 为了比较不同样本类型 (中流尿,导管尿,膀粘膜) 的微生物组合.
- 评估尿路微生物组的基于性别的变异,并确定潜在的膀癌生物标志物.
主要方法:
- 从50名经过尿道切除的膀癌患者收集了中间尿液,导管尿液和正常的膀粘膜组织.
- 使用16S rRNA基因片序列为微生物组分析.
- 将样本类型的微生物组组成以及膀癌患者和对照组之间的微生物组组成进行比较,考虑性别差异.
主要成果:
- 在粘膜组织和尿液样本之间观察到微生物组合的显著差异.
- 粘膜组织分析受到低生物量和污染的影响,导致专注于尿样.
- 与对照组相比,导管尿液显示膀癌患者的Curvibacter,特别是Curvibacter gracilis的丰度明显更高.
- 杆菌的患病率与高风险与低风险组中膀癌的严重程度增加相关.
结论:
- 导管尿是膀癌微生物组分析中最可靠的样本类型.
- 细菌Curvibacter可能与膀癌的严重程度有关,表明其作为诊断生物标志物的潜力.
- 需要进一步的研究来验证这些发现在更大的队列中,并探索Curvibacter和膀癌进展之间的机制联系.
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