益生菌及其代谢物的预防性疗效对抗 Staphylococcus epidermidis
Anna Phan1, Kanchan Thapa2, Muhammad Abrar Hashmi2
1Biological Sciences Program-Molecular and Cellular Biology, University of Maryland, College Park, State Maryland, MD 20742, USA.
BMC microbiology
|October 2, 2025
概括
乳酸菌 (Lacticaseibacillus rhamnosus) 和乳酸植物菌 (Lactiplantibacillus plantarum) 显示出强大的抗菌作用,可以对多药耐药的 Staphylococcus epidermidis 产生强烈的抗菌作用. 这些益生菌为控制S. epidermidis殖民和生物膜形成提供了有希望的替代品.
科学领域:
- 微生物学 微生物学
- 益生菌研究 益生菌研究
- 抗菌剂 抗菌剂 抗菌剂
背景情况:
- 史塔菲洛科克 (Staphylococcus epidermidis) 是一种常见的皮肤微生物和机会性病原体.
- 在S. epidermidis的抗生素耐药性构成了重大的健康挑战.
- 探索益生菌作为传统抗生素的替代品至关重要.
研究的目的:
- 评估Lacticaseibacillus rhamnosus和Lactiplantibacillus plantarum对抗多药耐药的S. epidermidis的疗效.
- 研究这些益生菌在控制S. epidermidis生长,殖民和生物膜形成方面的潜力.
主要方法:
- 与L. rhamnosus或L. plantarum一起共同培养S. epidermidis. 这两种植物.
- 通过殖民地计数来评估抗菌活性.
- 用来自益生菌的无细胞培养超眠剂 (CFCS) 治疗S. epidermidis.
- 使用光显微镜分析基因表达和细胞壁完整性.
主要成果:
- 共同培养显著降低了S. epidermidis的生长,在48小时后显著下降.
- 来自益生菌的CFCS强烈抑制了S. epidermidis的生长和生物膜的形成.
- 治疗CFCS导致关键的S. epidermidis代谢和细胞分裂基因的下调.
- 益生菌治疗损害了细菌细胞壁的完整性.
结论:
- L. plantarum和L. rhamnosus对抗多药耐药的S. epidermidis表现出强大的抗菌活性.
- 这些益生菌显示出作为治疗S. epidermidis感染的替代策略的巨大潜力.
- 这些发现支持使用益生菌来控制S. epidermidis的殖民,并减少生物膜的形成.
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