维生素D和骨健康:从生理功能到疾病关联
Yu Liu1,2, Wei Wang1,2, Yusheng Yang1
1Department of Orthopedics, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, 400038, People's Republic of China.
Nutrition & metabolism
|October 2, 2025
概括
维生素D (VD) 对骨健康和免疫功能至关重要. 研究强调其在骨质疏松症和关节炎等骨疾病中的作用,但需要更多的研究来证实其治疗益处.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 骨生物学 骨生物学 骨生物学
背景情况:
- 维生素D (VD) 是一种对平衡和骨代谢至关重要的二类激素.
- 新兴的研究突出显示了VD在免疫调节,炎症和慢性疾病调节中的重要作用.
- 本综述全面总结了目前关于风险疾病对骨健康的影响,其机制和临床相关性的研究.
研究的目的:
- 通过维生素D受体 (VDR) 审查维生素D (VD) 的新陈代谢和信号通路.
- 探索VDR多态化对疾病易感性的影响.
- 检查VD在先天性和适应性免疫中的双重作用及其与骨相关疾病的参与.
主要方法:
- 关于维生素D (VD) 和骨健康的当前研究的文献综述.
- 对VD代谢的分析,包括VD3和VD2转化为1,25-二氧维生素D.
- 检查涉及维生素D受体 (VDR) 的基因组和非基因组信号通路.
主要成果:
- 关于静脉疾病对骨关节炎 (OA) 症状和软骨退化的影响存在相互矛盾的证据.
- 维生素D缺乏会加剧骨质疏松症 (OP) 的骨损失,补充剂的有效性根据基线水平和摄入量而有所不同.
- 静脉疾病的免疫调节作用可能会降低类风湿性关节炎 (RA) 的活性,并有助于结核病的清除,尽管临床数据仍不确定.
结论:
- 维生素D (VD) 是骨免疫交叉的关键调解者.
- 需要进一步进行严格的翻译研究,以阐明各种疾病中静脉疾病的治疗潜力.
- 了解静脉疾病的复杂作用对于开发有效的骨和免疫健康策略至关重要.
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