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重编程细胞衰老和衰老钟用于晚期癌症免疫疗法

Huiting Yang^1,2, Dong Liu¹, Liewang Qiu³

¹Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, China.

Molecular cancer

|October 3, 2025

概括

细胞衰老在癌症中起着双重作用,抑制早期瘤,但促进晚期. 了解衰老的时钟和老化药物提供了新的个性化癌症治疗策略.

科学领域:

在瘤学瘤学.
地质科学是地球科学.
细胞生物学细胞生物学

背景情况:

细胞衰老,最初由细胞循环停止定义,现在包括由p53-p21CIP1和p16INK4A-Rb通路调节的更广泛的表型.
衰老细胞通过抑制早期瘤而影响癌症,但通过分泌和免疫调节功能促进晚期恶性瘤.
持续衰老的细胞会导致慢性炎症,免疫逃脱和纤维化,影响瘤的微环境.

研究的目的:

审查细胞衰老在癌症中的分子基础,作用和治疗含义.
探索老龄化时钟,生物年龄和癌症易感性之间的联系.
讨论针对癌症治疗的衰老细胞的当前和未来治疗策略.

主要方法:

关于细胞衰老,瘤微环境,衰老时钟和癌症治疗的文献综述.
对调节衰老的分子通路的分析 (p53-p21CIP1,p16INK4A-Rb).
在癌症治疗中检查老化剂和衰老时钟指标.

主要成果:

衰老细胞积聚在瘤微环境中,分泌出促炎细胞因子,改变免疫监测和细胞外基质.
老龄化时钟区分生物和时间年龄,改进了对个体癌症易感性的理解.
老化剂和适合老化时钟的免疫疗法在治疗与年龄相关的癌症方面表现有前途.

结论:

细胞衰老是癌症发展和进展的关键因素,对治疗有重大影响.
老龄化时钟为个性化癌症护理提供了一种新的方法,特别是在老年患者身上.
结合老化生物学,老年科学和瘤学,可以将癌症治疗转变为更加个性化和年龄意识的策略.

关键词:

老化的时钟表.细胞衰老细胞衰老免疫监视系统的监视瘤免疫疗法免疫疗法瘤微环境是一个微环境.

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