Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

1.8K
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
1.8K
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

986
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
986
Neural Regulation01:37

Neural Regulation

43.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
43.1K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A Diagnostic Dilemma of Emphysematous Liver Abscess with Gas under the Diaphragm: A Case Report and Review of Literature.

Journal of the West African College of Surgeons·2024
Same author

Dynamics of switching processes: general results and applications in intermittent active motion.

Soft matter·2024
Same author

Potential utility of anterior segment optical coherence tomography and biometry in differentiating plateau iris configuration from pupillary block.

Clinical & experimental optometry·2024
Same author

Disparities in casemix, acute interventions, discharge destinations and mortality of patients with traumatic brain injury between Europe and India.

Journal of global health·2024
Same author

Fronto-Orbital Advancement and Anterior Calvarial Remodeling for Trigonocephaly.

Neurology India·2024
Same author

Comparing the efficacy of multiple quantitative and qualitative ultrasound parameters for the diagnosis of carpal tunnel syndrome.

Journal of ultrasound·2024

相关实验视频

Updated: Jan 16, 2026

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
05:51

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

4.4K

需要制定基于共识的指导方针来评估帕金森病的横向性.

Emily Houston1, Sean Boyd2, Vivikta Iyer1

  • 1Binter Center for Parkinson's Disease & Movement Disorders, University of Vermont Medical Center University of Vermont Medical Center, USA; Department of Neurological Sciences, Larner College of Medicine, University of Vermont, USA.

Parkinsonism & related disorders
|October 3, 2025
PubMed
概括

大多数帕金森病患者与临床分期一致,但有些病例显示不一致. 这表明,除了肢体症状之外,还有其他因素影响Hoehn和Yahr的分期,这表明需要更明确的指导方针.

更多相关视频

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

3.3K
Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease
10:32

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

Published on: June 17, 2013

56.2K

相关实验视频

Last Updated: Jan 16, 2026

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
05:51

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

4.4K
Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease
06:45

Rating L-DOPA-Induced Dyskinesias in the Unilaterally 6-OHDA-Lesioned Rat Model of Parkinson's Disease

Published on: October 4, 2021

3.3K
Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease
10:32

Assessment of Sensorimotor Function in Mouse Models of Parkinson's Disease

Published on: June 17, 2013

56.2K

科学领域:

  • 神经学 神经学
  • 运动障碍 运动障碍

背景情况:

  • 帕金森病 (PD) 的分期对于临床评估和研究至关重要.
  • 霍恩和雅尔 (HY) 尺度是评分PD严重程度的常用方法.
  • 尾症状是PD评估的关键组成部分.

研究的目的:

  • 调查帕金森病横向性 (HY尺度) 和尾性帕金森症得分 (MDS-UPDRS第三部分) 之间的相关性.
  • 在PD患者中确定临床HY分期和客观尾运动功能的不一致.

主要方法:

  • 利用了来自帕金森氏症进展标志物倡议 (PPMI) 数据集的数据.
  • 与MDS-UPDRS第三部分附录子分数相关的Hoehn和Yahr (HY) 评级.
  • 分析了这些措施之间的一致性和不一致性程度.

主要成果:

  • 在HY分期和尾性帕金森症得分之间观察到高程度的一致性 (89.6%).
  • 在一小部分患者中发现了显著的不一致性 (10.4%).
  • 这种不一致表明除了尾症状之外的其他因素也会影响HY分期.

结论:

  • 虽然尾性帕金森症在很大程度上与临床HY分期一致,但存在矛盾.
  • 除了特定肢体运动缺陷之外的因素可能会影响帕金森病的整体临床表现和病期.
  • 可能需要标准化指导方针来完善临床分期并提高PD评估的一致性.