在患有重大抑郁症的青少年中,奖励相关的认知控制中的行为和神经功能障碍
Yiwen Qiu1,2, Haoran Dou1, Benjamin Becker3
1Institution for Brain and Psychological Science, https://ror.org/043dxc061Sichuan Normal University, Chengdu, China.
Psychological medicine
|October 3, 2025
概括
患有严重抑郁症 (MDD) 的青少年表现出认知控制受损,特别是在奖励环境中. 他们的大脑表现出前额叶皮层激活和连接能力的减少,这表明动机系统功能障碍.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 发展性精神病学是一个发展性精神病学.
背景情况:
- 奖励处理显著影响认知控制.
- 在青少年大抑郁症 (MDD) 中,奖励和认知控制之间的功能障碍相互作用尚未得到充分理解.
研究的目的:
- 为了研究奖励,认知控制和MDD青少年的大脑功能之间的相互作用.
- 检查青少年抑郁症中认知控制缺陷背后的神经机制.
主要方法:
- 35名患有MDD的青少年和29名健康对照 (HC) 在奖励和非奖励条件下完成了AX-持续性能测试 (AX-CPT).
- 功能近红外光谱 (fNIRS) 和等级漂移扩散建模 (HDDM) 用于评估行为和神经反应.
主要成果:
- 患有MDD的青少年表现出比HC更慢的反应时间和更高的错误率.
- 在奖励环境中,MDD组显示出较低的起始偏差和更广泛的决策值,前额叶皮层激活和连接性降低.
- 无症的严重程度与表现较差和前额部活化不那么灵活相关.
结论:
- 抑郁症青少年的认知控制障碍与激励系统功能障碍有关.
- 研究结果支持预期控制值 (EVC) 理论,强调奖励灵敏度下降和认知控制不灵活.
- 动机因素对于理解和治疗青少年抑郁症认知控制缺陷至关重要.
相关概念视频
Attention-Deficit/Hyperactivity Disorder
776
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
776
Depression: Overview
794
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
794
Self-Regulation
223
Self-regulation, also known as self-control, encompasses a range of cognitive and behavioral processes that allow individuals to adjust their internal states and outward actions to align with socially acceptable norms and long-term goals. It plays a fundamental role in adaptive functioning, from resisting impulsive behaviors to persisting through challenging tasks. While its benefits are widely recognized, self-regulation is not limitless. Muraven and Baumeister's theory posits that...
223


