从补丁到盘子:对患者系统性症状的评估,这些患者对二硫酸盐的补丁测试反应呈阳性
Sarah Karels1,2, Brailyn Weber1,3, Ella Chrenka4
1From the Department of Dermatology, Park Nicollet Contact Dermatitis Clinic, Park Nicollet, Minneapolis, Minnesota, USA.
Dermatitis : contact, atopic, occupational, drug
|October 3, 2025
概括
患有二硫酸接触过敏的人在摄入硫酸盐后经常出现全身症状. 这表明接触过敏和食物不耐受性之间存在联系,可能需要饮食指导.
科学领域:
- 皮肤病学 皮肤病学
- 过敏学 过敏学
- 临床免疫学临床免疫学
背景情况:
- 硫酸是已知的接触过敏原.
- 二硫酸盐接触过敏和全身硫酸盐不耐受性之间的关系尚不清楚.
研究的目的:
- 为了调查是否有阳性贴片检测二硫酸盐的患者在摄入硫酸盐后报告全身症状.
- 为了比较贴片测试阳性个体与贴片测试阴性对照个体的症状发生.
主要方法:
- 追溯横截面研究涉及82名参与者 (41个阳性,41个阴性二硫酸盐补丁测试).
- 标准化调查评估高硫酸盐食物/饮料消费后的症状 (头痛,咳,胃肠道不适).
- 分析症状的频率,严重程度和触发因素,比较两组.
主要成果:
- 与对照组 (26.8%) 相比,二硫酸盐贴片测试阳性组 (57.9%) 的系统性症状明显更为普遍.
- 在阳性组中,葡萄酒消费是症状的常见触发因素 (58.1%对25.6%).
- 观察到补丁测试反应的强度和症状频率/严重程度之间存在相关性.
结论:
- 患有二硫酸接触过敏的患者在摄入硫酸盐后更频繁地报告全身症状.
- 研究结果表明,接触过敏和全身硫酸盐不耐受性之间存在潜在的重叠.
- 饮食咨询可能有利于阳性二硫酸盐贴片试验的患者.
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