代谢需求动态中的神经灵活性揭示了性别特异性差异,并支持童年后期的认知
Aline Kotoski1, Sir-Lord Wiafe1, Vince D Calhoun1
1Tri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Atlanta, USA.
bioRxiv : the preprint server for biology
|October 3, 2025
概括
神经灵活性,而不是稳定性,有助于9-11岁儿童的认知. 大脑网络能量使用的性别差异很早就出现了,女性更喜欢灵活的状态,男性更稳定的状态.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 认知科学 认知科学
背景情况:
- 大脑网络代谢需求的动态协调对于认知发展至关重要.
- 缺乏了解这些动态中的性别特异性变化及其在童年后期的认知联系.
研究的目的:
- 为了研究9-11岁儿童大脑网络能量动态中的性别差异.
- 探索这些动态和认知表现之间的关系.
主要方法:
- 在ABCD研究中利用了2000名健康儿童 (9-11岁) 的休息状态fMRI数据.
- 应用时间解析的动态时间扭曲来测量振幅不匹配,作为相对能量需求的代理.
- 采用聚类来识别反复出现的大脑网络状态 (融合,分离,混合).
主要成果:
- 确定了三个不同的大脑网络状态:收,分歧和混合.
- 女性对灵活混合状态的参与度更高,而男性在融合和分离状态中花费的时间更长.
- 认知灵活性,处理速度和长期记忆与混合状态的时间增加和更高的过渡率相关,但停留时间更短.
结论:
- 神经灵活性,以动态网络协调为特征,支持儿童后期的认知功能.
- 大脑网络能量动态中的性别差异在青春期之前就显而易见.
- 在此期间,促进神经灵活性可能是认知发展的关键.
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