作为治疗目标,INTERLEUKIN-18治疗西方饮食诱导的心肌病
bioRxiv : the preprint server for biology
|October 3, 2025
概括
用IL-18结合蛋白 (IL-18BP) 阻断Interleukin-18 (IL-18) 在食西方饮食的小鼠中改善了心脏功能. 这种干预可以挽救腹筋功能障碍,而不依赖于体重增加或葡萄糖耐受性变化.
科学领域:
- 心血管研究研究心血管研究
- 代谢综合征是代谢综合征的一种.
- 免疫学 免疫学 免疫学
背景情况:
- 西方饮食 (WD) 高含和脂肪和糖会在小鼠中诱导肥胖和左心室功能障碍.
- 亲炎性细胞因子INTERLEUKIN-18 (IL-18) 参与调解这种心脏功能障碍.
- 这项研究研究了阻断IL-18.8的治疗潜力.
研究的目的:
- 为了确定阻断复合性小鼠IL-18结合蛋白 (IL-18BP) 是否可以在被WD养的小鼠中挽救心脏功能.
- 评估IL-18在饮食引起的心脏功能障碍中的作用.
主要方法:
- 成年C57BL/6J小鼠被养标准饮食 (SD) 或WD9周.
- 7周后,WD养的小鼠每天接受IL-18BP或对照剂的腹腔内注射,持续2周.
- 用多普勒心声学评估心脏功能,并通过ELISA测量IL-18血水平.
主要成果:
- 食WD显著增加了体重,降低了葡萄糖耐受性和减弱了腹功能 (增加了异体度放松时间-IRT和心肌性能指数-MPI-).
- 在WD食小鼠中,IL-18BP治疗显著改善了IRT和MPI.
- IL-18BP并没有显著改变食物摄入量,体重增加或葡萄糖耐受性.
结论:
- IL-18BP有效地挽救了WD诱导的心脏功能障碍的小鼠的心脏功能.
- IL-18BP的有益作用与体重或葡萄糖耐受性的变化无关.
- 这些发现强调了IL-18在饮食引起的心脏功能障碍中的关键和独立作用.
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