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螺旋质会损害丸的基因表达在Glossina fuscipes fuscipes中

Riccardo Piccinno¹, Giulia Fiorenza¹, Francesco Lescai¹

¹Department of Biology and Biotechnology "Lazzaro Spallanzani", University of Pavia, 27100 Pavia, Italy.

bioRxiv : the preprint server for biology

|October 3, 2025

概括

齐齐 (Glossina fuscipes fuscipes) 中的螺旋菌感染通过降低丸中关键基因的调节,显著影响雄性生殖. 这一发现对于开发新型生物控制策略来对抗松菌病载体至关重要.

科学领域:

昆虫学昆虫学是一门学科.
微生物学微生物学
遗传学是一个遗传学.

背景情况:

Glossina fuscipes fuscipes是撒哈拉以南非洲人类和动物三虫病的关键载体.
由于这种疾病的社会经济影响和有限的治疗选择,控制种群至关重要.
螺旋在G. f. fuscipes中的存在为新的控制策略提供了潜力,可能是通过赋予Trypanosoma感染的折射性.

研究的目的:

为了研究螺旋体感染对雄性Glossina fuscipes fuscipes的生殖能力的影响.
为了确定受Spiroplasma影响的特定分子通路,在雄性猫中.

主要方法:

基因表达差异分析在Spiroplasma感染和未感染的男性G. f. 状体的丸和男性辅助腺体 (MAG) 上进行.
分析的重点是识别基因与改变表达水平的基因,以应对螺旋体感染.

主要成果:

在受感染的男性的丸中观察到基因的显著下调.
与精子运动,能量代谢和线粒体功能相关的基因在丸中显著下调.
男性的辅助腺体表现出不那么明显的效果,不同表达的基因参与了抗菌活性和昼夜节律调节.

结论:

螺旋等离子体感染对雄性G. f. 管造成潜在的健康成本,特别是影响丸功能.
了解这些分子影响对于评估使用螺旋作为对的生物控制剂的可行性和潜在后果至关重要.

关键词:

不同的基因表达分析分析.能源的能量是能量的能量.我们的微生物群.生殖生殖的繁殖.在Rnaseqq.齐齐飞的飞行方式

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