功能性成像用于再生医学和组织工程结构:跟踪组织工程小肠支架的血管化
bioRxiv : the preprint server for biology
|October 3, 2025
概括
光声成像 (PAI) 在组织工程小肠 (TESI) 支架中非侵入性监测血管成熟度. 这项技术可以指导TESI植入的手术时间,改善临床翻译.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 医疗成像医学成像
背景情况:
- 组织工程小肠 (TESI) 需要omental植入以进行血管化.
- 目前的方法缺乏对血管成熟的非侵入性监测,延迟了最佳的外科手术时间.
- 光声成像 (PAI) 提供了实时血管评估的潜力.
研究的目的:
- 评估PAI在TESI支架中监测血管成熟度的能力.
- 为了将PAI发现与组织学和总体血管化评估相关联.
- 确定PAI在指导TESI临床翻译中的实用性.
主要方法:
- 使用电制造的管状TESI脚手架的制造.
- 在1个月和2个月的老鼠体内植入支架.
- 使用PAI进行非侵入性成像,以量化组织氧化和血红蛋白度.
主要成果:
- PAI成功检测到血管化的区域和时间变化.
- 顶部的脚手架壁表现出优越的血管成熟度,与底部的墙壁相比.
- PAI结果与总观测和组织学内皮细胞密度相关得很好.
结论:
- 在腹部组织工程结构中,PAI是用于非侵入性评估血管成熟度的可行工具.
- 这种成像模式可以为TESI手术的手术时间提供信息.
- PAI促进了TESI的临床前开发和临床翻译.
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