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Updated: Jan 16, 2026

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与结肠直肠癌相关的PCBP1突变以主导负面的方式破坏蛋白质稳定性

Paige V Blinkiewicz1,2, Nicole C Hoenes2, Myra X Afzal3

  • 1Dartmouth Cancer Center, Lebanon NH.

bioRxiv : the preprint server for biology
|October 3, 2025
PubMed
概括

结肠直肠癌突变的聚C结合蛋白1 (PCBP1) 破坏蛋白质的稳定,导致其水平降低. 这些突变PCBP1蛋白质随后抑制正常PCBP1的功能,推动瘤生长.

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