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Updated: Jan 16, 2026

Synthesis and Characterization of an Aspirin-fumarate Prodrug that Inhibits NFκB Activity and Breast Cancer Stem Cells
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Published on: January 18, 2017

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通过ACSS2-介导的代谢-表观遗传交叉声驱动了全方位抵抗,并代表了一个新的治疗目标

Ayça N Mogol, Jin Young Yoo, Alicia Arredondo Eve

    bioRxiv : the preprint server for biology
    |October 3, 2025
    PubMed
    概括

    将Fulvestrant与ACSS2抑制剂结合使用,可以通过阻断表观遗传变化来克服ER+乳腺癌的内分泌治疗阻力. 这种新的方法针对癌细胞的适应,有可能减少转移并改善存活率.

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