甲状腺激素耐药性指数及其与中国甲状腺素受试者胰岛素耐药性的相关性
Ruixiang Cui1, GuiHua Li2, Ying Wei1
1Department of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, No. 8, Gongti South Road, Chaoyang District, Beijing 100020, China.
International journal of endocrinology
|October 3, 2025
概括
降低甲状腺激素敏感性与正常体重和超重的甲状腺成年人中较高的胰岛素抵抗 (IR) 有关. 然而,在肥胖个体中没有观察到这种关联,这表明受身体质量指数 (BMI) 影响的复杂关系.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 甲状腺功能 甲状腺功能
- 胰岛素耐药性 胰岛素耐药性是一种
背景情况:
- 甲状腺激素在调节新陈代谢方面发挥着至关重要的作用.
- 胰岛素抵抗 (IR) 是代谢障碍的一个关键因素.
- 不同类别的体重指数 (BMI) 之间的甲状腺激素敏感性和IR之间的关系需要进一步研究.
研究的目的:
- 分析甲状腺激素敏感性和胰岛素抵抗 (IR) 之间的关联.
- 为了在正常体重,超重和肥胖的BMI类别中探索 euthyroid个体中的这种关系.
主要方法:
- 分析了32478名甲状腺功能良好的参与者,按BMI分类:正常体重 (<25 kg/m2),超重 (2529.9 kg/m2) 和肥胖 (≥30 kg/m2).
- 甲状腺激素敏感性评估使用甲状腺反量基指数 (TFQI),TSH指数 (TSHI) 和甲状腺增生T4抵抗指数 (TT4RI).
- 胰岛素耐药性 (IR) 通过使用甘油三-葡萄糖 (TyG) 指数,血无氧原体指数 (AIP) 和胰岛素耐药性代谢评分 (METS-IR) 进行评估.
主要成果:
- 在正常体重和超重群体中,降低甲状腺激素敏感度 (更高的TFQI,TSHI,TT4RI) 与更高的IR (更高的TyG指数) 有正相关.
- 后勤回归表明,在正常体重和超重组中,TFQI,TSHI和TT4RI的最高四分位数的个体中,TyG指数升高的几率更高.
- 在肥胖组 (BMI ≥30 kg/m2),虽然甲状腺指数和TyG之间观察到正相关性,但高TyG的关联在所有措施中都没有统计学意义.
结论:
- 降低对甲状腺激素的敏感性与正常体重和超重的甲状腺成年人胰岛素耐药性增加有关.
- 这种关联在肥胖个体中没有显著意义,表明甲状腺-胰岛素耐药性关系的BMI依赖差异.
- 需要进一步的研究来阐明这些BMI特定关联背后的机制.
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