加速衰老动物模型和牙科中的应用:一个范围审查
Si-Wei Wang1,2, Jia-Yu Mou1, Jia-Rui Jiang1
1Key Laboratory of Oral Disease Research, School of Stomatology, Zunyi Medical University, Zunyi, China.
Journal of dental sciences
|October 3, 2025
概括
加速衰老模型在口腔健康研究中显示出前景,特别是在牙周炎和糖尿病方面. 本综述强调了它们在研究衰老特征和开发老年口腔护理策略中的使用.
科学领域:
- 老年学是指老年学的学科.
- 口腔生物学 口腔生物学
- 生物医学研究生物医学研究
背景情况:
- 加速衰老模型在衰老研究中至关重要,但在牙科研究中未得到充分利用.
- 了解细胞衰老对于解决口腔健康下降至关重要.
研究的目的:
- 在口腔健康研究中对加速衰老模型的应用进行范围审查.
- 确定研究的常见模型,生物标志物和口腔疾病.
主要方法:
- 在PubMed和Web of Science的系统文献搜索 (2020年1月至2025年3月).
- 遵循PRISMA-ScR指南;包括29个体内研究.
- 在动物模型,诱导方法,衰老生物标志物和结果上提取数据.
主要成果:
- 确定了三种模型类型:化学,物理压力和遗传诱导.
- 牙周炎 (41.4%) 和唾液腺功能障碍是主要研究领域.
- 常见的衰老特征包括细胞循环停止,分泌表型和氧化应激.
结论:
- 加速衰老模型为口腔衰老提供了宝贵的见解,特别是在牙周炎和糖尿病方面.
- 鼠标是主要的模型; 糖尿病诱导的衰老经常被使用.
- 整合多个生物标志物可以完善老年口腔护理的模型.
相关概念视频
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The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or grinding food.