一个患有全身性红斑狼和保存功能的患者的埃尔塔因诱导脑病变:一个诊断挑战
Shreya Muralidharan1, Elangovan Raman2, Sorabh Sharma3
1Internal medicine, Vydehi Institute of Medical Sciences and Research Centre, Bengaluru, IND.
Cureus
|October 3, 2025
概括
埃尔塔胺可以引起神经毒性,如脑病变,即使在没有脏问题的患者中也是如此. 这一案例凸显了在老年患者中考虑药物诱导的神经副作用的重要性.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 碳胺抗生素对于治疗多抗药性感染至关重要.
- 神经毒性,包括脑病变,是已知的但不太常见的卡巴胺的副作用,通常与功能障碍有关.
- 老年患者特别容易受到药物不良反应的影响.
研究的目的:
- 报告一个年龄较大且功能保留的老年患者中埃尔塔因引起的神经毒性的病例.
- 突出卡巴胺神经毒性的潜力,独立于功能障碍.
- 为了强调需要对埃尔塔内姆的副作用保持警.
主要方法:
- 一个老年女性患者的病例报告,患有全身性红斑狼和高血压.
- 开始对多药耐药性大肠杆菌尿路感染治疗.
- 对神经症状 (幻觉,混乱) 的临床观察和诊断工作.
- 停止使用埃尔塔和注射静脉胺.
主要成果:
- 患者在开始服用埃尔塔内姆药物后不久就出现了急性脑病变,出现了生动的幻觉和混乱.
- 广泛的调查排除了感染性,代谢性和自身免疫性原因.
- 在停止服用埃尔塔内姆和接受胺治疗后,神经症状迅速消失.
- 尽管患者保持了功能,但发生了这种情况.
结论:
- 埃尔塔胺可以诱导神经毒性,表现为脑病变,即使在正常功能患者中也是如此.
- 这一案例扩大了对卡巴因引起的神经毒性的理解,特别是在老年患者中.
- 临床医生应考虑埃尔塔因作为敏感个体潜在的脑病变的原因,无论状况如何.
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