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传统ICSI和救援ICSI在没有严重男性因子和低卵细胞产量患者中的比较

Mingzhao Li¹, Wennan Chen¹, Xia Xue¹

¹The ART Center, Northwest Women's and Children's Hospital, Xi'an, China.

Frontiers in endocrinology

|October 3, 2025

概括

早期救援细胞体内精子注射 (R-ICSI) 对卵细胞产量低且男性因子轻微的患者提供与传统ICSI相比的生殖结果. 这项研究发现类似的怀孕和活产率,尽管R-ICSI.有更高的多原核率.

科学领域:

生殖医学生殖医学
胚胎学胚胎学
不孕症治疗不孕症治疗

背景情况:

内细胞质精子注射 (ICSI) 是一种关键的辅助生殖技术.
低卵细胞产量和不严重的男性因素在ICSI周期中带来了独特的挑战.
救援ICSI (R-ICSI) 是一种替代性受精方法,在特定的患者群体中正在探索早期的R-ICSI.

研究的目的:

评估早期救援细胞体内精子注射 (R-ICSI) 的有效性和安全性.
为了比较早期R-ICSI和常规ICSI之间的生殖结果,在患有低卵细胞产量和不严重的男性因子的患者中.

主要方法:

一个回顾性队列分析,将604个常规ICSI周期与116个早期R-ICSI周期进行比较.
纳入标准:第一个辅助生殖技术 (ART) 周期,3-5个取回的卵细胞,正常或轻微受损的精子参数.
评估的结果包括受精率 (MII,2PN,MPN),胚胎发育 (D3质量好,D3可用,母细胞囊形成) 和怀孕结果 (怀孕,临床怀孕,正在进行的怀孕,活产).

主要成果:

在传统ICSI和早期R-ICSI之间,在MII,2PN,D3优质胚胎,D3可用胚胎或芽细胞形成率方面没有发现显著差异.
早期R-ICSI组的多核 (MPN) 率明显高 (6.33%) 与传统ICSI (1.02%) 相比.
怀孕,临床怀孕,正在进行的怀孕和活产率在两组之间是可比的.

结论:

早期的R-ICSI可以在卵细胞产量低且男性因子不严重的夫妇中获得与传统ICSI相似的生殖结果.
尽管MPN率较高,但早期R-ICSI在活产率方面表现出类似的有效性.
这表明,早期R-ICSI对于精选的不育夫妇来说是一个可行的选择.

关键词:

美国国务院调查局 (ICSI)在c-IVF中.没有受精失败是受精失败.生殖结果的结果.救援 ICSI 的情况.

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