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心肌炎或"热阶段"的失律性心肌病变? 一个案例系列

André Ferreira¹, Rita Teixeira¹, Pedro Brás¹

¹Department of Cardiology, Hospital de Santa Marta, Unidade Local de Saúde de São José, R. de Santa Marta 50, 1169-024 Lisbon, Portugal.

European heart journal. Case reports

|October 3, 2025

概括

节律失调性心肌病 (ACM) 在急性炎症阶段可以模仿心肌炎. 通过先进的成像和遗传检测来识别这种"热期"是准确诊断和管理年轻男性心律失常风险的关键.

科学领域:

心脏病学心脏病学
遗传学是一个遗传学.
医疗成像医学成像

背景情况:

节律失常性心肌病 (ACM) 涉及纤维脂肪心肌置换,导致心律失常.
在ACM中,急性炎症期 ("热期") 可以模仿心肌炎,使诊断复杂化.
由于临床表现重叠,将ACM与心肌炎区分开来是一项挑战.

研究的目的:

突出ACM炎症"热期"所带来的诊断挑战.
为了说明先进的成像和基因测试在区分ACM和心肌炎方面的实用性.
强调早期识别和管理心律失常风险在ACM中的重要性.

主要方法:

介绍了两个年轻男性患有ACM的案例研究.
使用心脏磁共振 (CMR) 成像与晚期加多增强 (LGE).
进行基因测试以确定DSP和LMNA基因中的突变.

主要成果:

两位患者都呈现出暗示心肌炎的症状.
在非缺血性分布中,CMR揭示了特征性的LGE模式.
基因测试证实了LMNA和DSP基因中的病原性突变,证实了ACM.
一名患者因心律失常风险而接受植入式心脏转换器-除器 (ICD).

结论:

ACM的"热阶段"需要在表现为心肌炎样症状的患者中仔细考虑.
基因检测和CMR是ACM诊断和风险分层的重要工具.
管理策略,包括心律失常预防 (例如,ICD),对于患有与ACM相关的DSP和LMNA突变的患者至关重要.

关键词:

节律失常性心肌病变症 (arrhythmogenic cardiomyopathy) 是一种导致心律失常的心脏病变症.心脏磁共振是一种心脏磁共振.案件系列案件系列在 DSP 中,提供 DSP 服务.基因突变是一种基因突变.热阶段是热的阶段.LMNA LMNA 在线观看肌心炎是一种心肌炎.

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