制备和描述含有米卡颗粒的基甲基纤维素膜,并评估其抗菌活性
Lalitha S Jairam1, Sivaranjani Gali2, R Deveswaran3
1Department of Pediatric and Preventive Dentistry, Faculty of Dental Sciences, Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India.
International journal of clinical pediatric dentistry
|October 3, 2025
概括
含有粒的基甲基纤维素 (HPMC) 薄膜是作为化物的替代品来预防牙损伤而开发的. 8%的-HPMC薄膜对S. mutans表现出显著的抗菌活性,显示出对抗菌原应用的前景.
科学领域:
- 材料科学 材料科学 材料科学
- 生物材料工程 生物材料工程
- 牙科研究 牙科研究
背景情况:
- 牙损是一种流行的微生物疾病,影响牙质和牙.
- 目前的预防方法,主要是化物,有局限性,包括毒性和需要专业应用.
- 需要替代性,有效的抗菌原剂.
研究的目的:
- 准备和描述含有 mica 颗粒的基甲基纤维素 (HPMC) 薄膜.
- 评估这些新型HPMC-mica薄膜对Streptococcus mutans的抗菌特性.
- 探索基于的薄膜作为牙腐烂预防的替代品的潜力.
主要方法:
- 用不同度的光 (2%,4%,6%,8%) 和对照剂制备了HPMC薄膜.
- 用FTIR,SEM和EDX来表征电影;测量物理性质 (厚度,pH,分解).
- 对S. mutans的抗菌活性通过亚格盘扩散,MIC和MBC进行评估.
主要成果:
- 在HPMC薄膜中的结合得到了FTIR,XRD和SEM的证实.
- 8%的-HPMC薄膜显示出最大的抑制区域 (14毫米) 对S. mutans.
- 最低的最小抑制度 (MIC) 和最小杀菌度 (MBC) 值在8%的-HPMC组中观察到.
结论:
- 含有的HPMC薄膜易于配制,并显示出显著的抗菌活性.
- 这些新的电影显示了作为有效的抗菌原材料的希望.
- 基于米卡的HPMC薄膜为化物提供了一个潜在的替代方案,用于预防牙损伤.
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