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单射式多参数核磁共振 (MRI) 用于从动态葡萄糖增强对比效应中分离T₂的效应

Junxian Jin¹, Haizhen Ding², Zhekai Chen¹

¹Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, School of Electronic Science and Engineering, National Model Microelectronics College, Xiamen University, Xiamen, China.

|October 3, 2025

概括

这项研究引入了一种新的MRI方法,通过纠正混因素来准确测量葡萄糖吸收. 这提高了动态葡萄糖增强 (DGE) 成像用于癌症和大脑研究的特异性.

科学领域:

生物医学成像技术生物医学成像技术
磁共振成像技术磁共振成像技术
代谢成像 - 代谢成像

背景情况:

葡萄糖是一种关键的代谢基质和疾病的生物标志物.
使用化学交换和转移 (CEST) 的动态葡萄糖增强 (DGE) MRI 绘制葡萄糖吸收图.
DGE-MRI的量化因葡萄糖诱导的T2放松变化而复杂.

研究的目的:

开发和验证一种多参数CEST (MP-CEST) MRI方法,以准确量化葡萄糖摄取量.
在DGE-MRI中纠正T2放松混效应.
提高代谢成像的特异性和稳定性.

主要方法:

开发了一次单射MP-CESTMRI序列,使用多回声SPEN同时获得T2和质子密度 (PD) 地图.
实施了两步校正策略,使用和加权PD图和T2图与Bloch-McConnell模拟.
在幻影和体内大鼠大脑和瘤异种移植模型中验证了框架.

主要成果:

在幻影中,在T2和PD量化方面取得了高精度 (R2>0.99).
在体内证明了DGE信号与T2值之间的相关性显著减少.
显示了与葡萄糖相关的对比度的提高特异性和T2地图的补充生理信息.

结论:

MP-CEST方法提高了DGE量化的准确性和稳定性.
这种方法为代谢成像提供了一个更全面的框架.
该技术适用于瘤和神经学研究.

关键词:

化学交换和转移化学交换和转移动态葡萄糖增强增强的动态葡萄糖摄取葡萄糖的时间多个参数的多个参数.这是一次单一的射击.

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Magnetic Resonance Imaging

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