骨髓瘤性肺溢液揭示了潜在的血细胞骨髓瘤:一种不常见的初始呈现
Alexandra K Mawlong1, Pranjal Kalita1, Humsheer S Sethi2,3
1Pathology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, IND.
Cureus
|October 3, 2025
概括
骨髓瘤性流 (MPE) 是一种罕见的血细胞骨髓瘤 (PCM) 并发症,表明疾病具有侵略性. 这一案例突显了膜液细胞学.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
背景情况:
- 骨髓瘤性流 (MPE) 是血细胞骨髓瘤 (PCM) 的一个不常见的表现.
- MPE与瘤单克隆血细胞的增殖有关,并且通常意味着一种积极的疾病过程.
- 在PCM患者中,MPE的发病率显著稀少,这使得早期诊断具有挑战性.
研究的目的:
- 报告PCM与MPE病例,强调诊断挑战和预后.
- 突出表液细胞学在诊断MPE中的作用.
- 强调早期识别和评估在管理PCM与MPE中的重要性.
主要方法:
- 一个55岁的男性病例报告,患有渐进性呼吸不良和背部疼痛.
- 诊断工作包括胸部X射线图,肺部液体分析 (细胞形态学,细胞块,腺脱氨酶),血清蛋白电泳,生化研究,骨X射线图和骨髓检查.
- 免疫类型定型通过CD138阳性和卡帕轻链限制证实了血细胞系和克隆性.
主要成果:
- 胸腔液分析显示出与非典型的血细胞和血突破物的排泄,这表明MPE.
- 血清蛋白质电泳显示出单克隆的"M"峰值;生化测试表明高血症,贫血和功能障碍.
- 骨髓检查证实PCM有70%的血细胞,确定了PCM与MPE的诊断.
结论:
- 胸腔液细胞学对于诊断PCM的非典型表现至关重要,例如MPE.
- 在PCM患者中,MPE与预后不佳和侵袭性疾病有关.
- 及时识别和全面评估对于MPE病例的有效患者管理至关重要.
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