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一个受体电机驱动的电子捐赠者-受体超分子支架,用于成像引导的瘤治疗

Canze Zheng¹, Liwei Zhu², Jianyu Zhang³

¹College of Chemistry and Materials Science, Jinan University Guangzhou 510632 China chenming@jnu.edu.cn.

Chemical science

|October 3, 2025

概括

这项研究引入了一种新的超分子策略,用于制造高效的近红外 (NIR) 光热剂. 开发的纳米颗粒显示出优异的光热转换,并有效用于光声成像和癌症治疗.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

传统的光热剂通常依赖于复杂的合成.
开发高效且易于使用的NIR光热剂对于生物医学应用至关重要.

研究的目的:

开发一种新的超分子策略,用于制造高效的NIR光热剂.
研究开发的纳米粒子的光热特性,成像能力和治疗效果.

主要方法:

使用1,4,5,8,9,11-hexaazatriphenylenehexacarbonitrile (HAT-CN) 作为受体和烯作为捐赠体制造一个超分子复合体.
描述该综合体的光热特性,包括加热效应和转换效率.
对纳米颗粒 (NP) 进行 in vitro 和 in vivo 光声成像和光热治疗的评估.

主要成果:

超分子复合体表现出强大的NIR吸收和高效的光热转换 (高达59.4%).
在激光照射下,纳米颗粒显示出快速加热效应超过190°C.
通过光热免疫调节成功应用NP用于体外/体内光声学成像和显著的瘤切除在小鼠.

结论:

电静力驱动的超分子策略为设计先进的NIR光热剂提供了一种简单而经济的方法.
开发的纳米粒子显示出生物医学应用的巨大潜力,包括成像和癌症治疗.
这项工作加速了有效的NIR光热剂在医学中的实际应用.

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