在神经性厌食症中绘制灰质变化:一种功能连接网络方法
HuCheng Yang1,2, Shu Wang1, HuaLiang Li3
1Department of Radiology, The Yancheng School of Clinical Medicine of Nanjing Medical University, Yancheng Third People's Hospital, Yancheng, China.
Frontiers in nutrition
|October 3, 2025
概括
神经性厌食症 (AN) 涉及到常见的大脑网络中断,特别是在听觉,默认模式和感觉运动网络中. 这些发现提供了对神经生物学机制的洞察力,以及对AN的潜在治疗点.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 基于voxel的形态测量 (vbm) 研究显示在神经性厌食症 (an) 中不一致的灰质 (gm) 变化.
- 这些转基因变化的融合在AN中的特定大脑网络上仍然不明确.
研究的目的:
- 系统地审查和识别与AN中转基因变异相关的常见大脑网络.
- 利用人类连接组项目 (HCP) 数据集和功能连接网络映射 (FCNM) 进行网络层面的分析.
主要方法:
- 在PubMed,Embase和Web of Science数据库中的系统文献搜索,截至2024年10月10日.
- 包括26项研究,包括667名AN个体和659名健康对照 (HC).
- 应用FCNM和HCP数据集来识别常见的中断神经网络.
主要成果:
- 在AN中常见的神经网络中断包括听觉网络,腹部和背部默认模式网络 (DMN) 和感觉运动网络 (SMN).
- 亚组分析表明,仅女性,青少年和成人亚组中受影响网络的变化.
- 整合HCP数据和FCNM发现了网络层面的异常.
结论:
- 在AN中异质的GM变化与听觉,DMN和SMN的常见异常有关.
- 这些网络中断与扭曲的身体形象,情绪失调和感官运动整合缺陷相关.
- FCNM提供了关于AN神经生物学的统一网络视角,指导治疗策略.
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