从治疗尿路感染到农细胞形成
Amit Katyal1, Nikunj Tiwari1, Vaka Rajshekhar1
1Department of Medicine, Naval Institute of Medical Sciences, INHS Asvini Hospital, Mumbai, Maharashtra, India.
Journal of family medicine and primary care
|October 3, 2025
概括
亲肠道福米可以引起白细胞严重下降的腺细胞症,特别是在患有慢性病的患者中. 这一案例突显出一种罕见但可能致命的副作用,需要立即停止药物治疗以恢复.
科学领域:
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 传染性疾病 传染性疾病
背景情况:
- 抗生素耐药性需要探索其他替代药物,如管菌素.
- 氏素表现出广泛的活性,包括对抗多药耐药 (MDR) 和广泛耐药 (XDR) 细菌.
- 福斯福米的常见副作用包括电解质失衡;严重的血液学影响很少见.
研究的目的:
- 在慢性脏病患者中报告一种罕见的通过肠道输入菌素诱导的细胞瘤病例.
- 为了突出严重的,特异性的不良反应的潜力,对斯福米辛.
- 为了贡献关于素诱导的中性质减退/农核细胞瘤的有限文献.
主要方法:
- 一个21岁的女性患者的病例报告,患有末期脏疾病.
- 治疗多药耐药生物体 (MDRO) 尿路感染,使用可注射福米.
- 在福斯福米辛治疗期间监测全血细胞计.
主要成果:
- 患者经过两天的注射氏菌素治疗后出现严重的白血病 (白细胞计数降至1700/克) .
- 中性粒细胞数量下降到493个细胞/μL,这与农细胞形成相一致.
- 在停止福米后,白血球数量迅速正常化.
结论:
- 亲肠道福米可以诱导亚核细胞瘤,即使在没有先前血液问题的患者中也是如此.
- 这种不良影响似乎是特异性的,并且需要对慢性病患者进行警监测.
- 迅速停止药物治疗导致康复,强调了认识到这种罕见并发症的重要性.
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